оплата за 0,5 суток (дневная, после расчетного часа).
Docetaxel is the most effective chemical agent used in the treatment of hormone-resistant prostate cancer (HRPC). Three different docetaxel-based combinations were tested. The study included 30 patients with HRPC: 10 patients received chemotherapy as intravenous docetaxel, 75 mg/m2 once every 21 days with prednisolone, 10 mg/day (DP); other 10 patients had docetaxel, 75 mg/m2, estramustin, 300 mg/m2 daily, and prednisolone, 10 mg daily (DEP); 10 more patients received a combination of doxorubicin, 20 mg/m2 on day 1 of weeks 1, 3, and 5, ketoconazole, 1200 mg/day on days 1-7 of weeks 1, 3, and 5, docetaxel, 20 mg/m2 on day 1 of weeks 2, 4, and 6, estramustin, 420 mg/day on days 1-7 of weeks 2, 4, and 6, prednisolone, 10 mg daily (DEKP). The study revealed that all these three combinations have about the same efficacy; with their use, the clinical improvement rate was 70-0%. Thus, the use of docetaxel in different combinations is an effective treatment for HRPC
Objective: to evaluate the pharmacodynamic equivalence of 3-month and 28-day formulations of tryptoreline, a sustained-release luteining hormone (LH)-releasing hormone analogue. Subjects and methods. The patients who had a verified diagnosis of locally advanced or metastatic prostate cancer were randomized into groups to have either one injection of a 3-month dosage form (n = 63) or 3 injections of a 28-day formulation at 28-day intervals (n = 68). The onset rate of drug-induced castration, which was defined as a percentage of the patients achieving a plasma testosterone level of ≤0.5 ng/ml, was compared on day 84 (i.e. thrice every 28 days). The plasma profiles of testosterone, LH, and tryptoreline, as well as the changes in the plasma concentration of prostate-specific antigen (PCA) from the baseline values were estimated within 3 months (from the initiation of therapy to day 91). Results. In the 3-month and 28-day groups, the onset rate of drug-induced castration was 98 and 96%, ...
форма развития и продвижения туризма, направленная на сближение целей и ожиданий «гостя» и «хозяина», туризм, альтернативный массовому с массовым производством и массовым потреблением, активно использующему природные и культурные ресурсы дестинации.
разновидность английского завтрака, то есть полный завтрак, который обычно включает в себя фруктовый сок, кофе или чай с джемом, тосты, масло и горячее блюдо (овсяную кашу, яичницу с ветчиной и др.).
набор блюд, который включает в себя, в отличие от легкого континентального завтрака, полный набор блюд, предлагаемых путешественникам в утренний период в отелях, ресторанах, кафе; обычно состоит из фруктового сока, чая или кофе, булочки с маслом, джема, гренок и горячего блюда (овсяной каши, бекона, яичницы, сосиски).
